Encapsulation of α-lipoic acid intochitosan and alginate/gelatin hydrogel microparticles and its in vitro antioxidant activity
| Autor: | Vidović Bojana B., Milašinović Nikola Z., Kotur-Stevuljević Jelena M., Dilber Sanda P., Kalagasidis-Krušić Melina T., Đorđević Brižita I., Knežević-Jugović Zorica D. |
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| Jazyk: | English<br />Serbian |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Hemijska Industrija, Vol 70, Iss 1, Pp 49-58 (2016) |
| Druh dokumentu: | article |
| ISSN: | 0367-598X 2217-7426 |
| DOI: | 10.2298/HEMIND141119010V |
| Popis: | Alpha-lipoic acidis an organosulphur compound well-known for its therapeutic potential and antioxidant properties. However, the effective use of α-lipoic acid depends on biological plasma half-life and its preserving stability, which could be improved by encapsulation. In this study, α-lipoic acid was incorporated into chitosan microparticles obtained by reverse emulsion crosslinking technique, as well as into microparticles of alginate/gelatin crosslinked with zinc ions. Encapsulation of α-lipoic acid in both cases was carried out by swelling of synthesized dried microparticles by their dipping in a solution of the active substance under strictly controlled conditions. Encapsulation efficiency of α-lipoic acid obtained in this study was up to 53.9 %. The structural interaction of α-lipoic acid with the carriers was revealed by Fourier transform infrared spectroscopy. In vitro released studies showed that controlled release of α-lipoic acid was achieved through its encapsulation into chitosan microparticles. The results of in vitro antioxidative activity assays of released α-lipoic acid indicated that antioxidant activity was preserved at a satisfactory level. These obtained results suggested that chitosan microparticles could be suitable for modeling the controlled release of α-lipoic acid. [Projekat Ministartsva nauke Republike Srbije, br. III 46010 i br. III46001] |
| Databáze: | Directory of Open Access Journals |
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