6-Cyclohexylmethyl-5-ethyl-2-[(2-oxo-2-phenylethyl)sulfanyl]pyrimidin-4(3H)-one
| Autor: | Wan-Lu Yan, Qiong Guo, Cong Li, Xiao-Ying Ji, Yan-Ping He |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Acta Crystallographica Section E, Vol 67, Iss 2, Pp o534-o534 (2011) |
| Druh dokumentu: | article |
| ISSN: | 16005368 1600-5368 |
| DOI: | 10.1107/S1600536811003175 |
| Popis: | In the title compound, C21H26N2O2S, the cyclohexane ring adopts a chair conformation. The angle at the methylene bridge linking the pyrimidine and cyclohexane rings is 113.41 (13)°. This is in the range considered optimal for maximum activity of non-nucleoside reverse transcriptase inhibitors. In the crystal, molecules are connected into centrosymmetric dimers via pairs of N—H...O hydrogen bonds. |
| Databáze: | Directory of Open Access Journals |
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