The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury
| Autor: | M. Elias-Miró, M. B. Jiménez-Castro, M. Mendes-Braz, A. Casillas-Ramírez, C. Peralta |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | PPAR Research, Vol 2012 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1687-4757 1687-4765 |
| DOI: | 10.1155/2012/802384 |
| Popis: | Strategies to improve the viability of steatotic livers could reduce the risk of dysfunction after surgery and increase the number of organs suitable for transplantation. Peroxisome proliferator-activated receptors (PPARs) are major regulators of lipid metabolism and inflammation. In this paper, we review the PPAR signaling pathways and present some of their lesser-known functions in liver regeneration. Potential therapies based on PPAR regulation will be discussed. The data suggest that further investigations are required to elucidate whether PPAR could be a potential therapeutic target in liver surgery and to determine the most effective therapies that selectively regulate PPAR with minor side effects. |
| Databáze: | Directory of Open Access Journals |
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