Effect of sterilization on the properties of CDHA-OCP-beta-TCP biomaterial

Autor: Loreley Morejón-Alonso, Raúl García Carrodeguas, José Ángel Delgado García-Menocal, José Antonio Alonso Pérez, Salvador Martínez Manent
Jazyk: angličtina
Rok vydání: 2007
Předmět:
Zdroj: Materials Research, Vol 10, Iss 1, Pp 15-20 (2007)
Druh dokumentu: article
ISSN: 1516-1439
DOI: 10.1590/S1516-14392007000100005
Popis: The effect of the method of sterilization on the physical, chemical and mechanical properties of a new bone repairing material was studied. The material was obtained by thermal hydrolysis of beta-tricalcium phosphate/orthophosphoric acid cement and was composed of calcium deficient hydroxyapatite, octacalcium phosphate (OCP), and beta-tricalcium phosphate. Partial decomposition of the OCP was observed after sterilization for the three methods. Decomposition increased to the following sequence of sterilization methods: ethylene oxide; autoclaving; dry oven. On the other hand, mechanical strength decreased with regard to non sterilized material in the sterilization sequence: ethylene oxide; dry oven; autoclaving. The compressive strength was 8.5 ± 1.0; 9.0 ± 1.2; 8.2 ± 0.8 and 6.5 ± 1.0 MPa, whereas diametral tensile strength was 2.1 ± 0.3; 2.5 ± 0.1; 1.9 ± 0.9 and 1.6 ± 0.3 for the material sterilized by ethylene oxide, dry oven, and autoclaving, respectively. Several compositional and microstuctural changes were detected after dry heat and autoclave sterilization. Ethylene oxide sterilization had lesser effect on the chemical composition and strength than dry heat and autoclaving.
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