pH-Sensitive Micelles Based on Double-Hydrophilic Poly(methylacrylic acid)-Poly(ethylene glycol)-Poly(methylacrylic acid) Triblock Copolymer

Autor: Tao Youhua, Liu Ren, Liu Xiaoya, Chen Mingqing, Yang Cheng, Ni Zhongbin
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Zdroj: Nanoscale Research Letters, Vol 4, Iss 4, Pp 341-343 (2009)
Druh dokumentu: article
ISSN: 1931-7573
1556-276X
DOI: 10.1007/s11671-009-9249-2
Popis: Abstract pH-sensitive micelles with hydrophilic core and hydrophilic corona were fabricated by self-assembling of triblock copolymer of poly(methylacrylic acid)-poly(ethylene glycol)-poly(methylacrylic acid) at lower solution pH. Transmission electron microscopy and laser light scattering studies showed micelles were in nano-scale with narrow size distribution. Solution pH value and the micelles concentration strongly influenced the hydrodynamic radius of the spherical micelles (48–310 nm). A possible mechanism for the formation of micelles was proposed. The obtained polymeric micelle should be useful for biomedical materials such as carrier of hydrophilic drug.
Databáze: Directory of Open Access Journals
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