Effect of Genistein and L-Carnitine and Their Combination on Gene Expression of Hepatocyte HMG-COA Reductase and LDL Receptor in Experimental Nephrotic Syndrome
| Autor: | Abbas YOUSEFINEJAD, Fereydoon SIASSI, Abbas MIRSHAFIEY, Mohammad-Reza ESHRAGHIAN, Fariba KOOHDANI, Mohammad Hassan JAVANBAKHT, Reza SEDAGHAT, Atena RAMEZANI, Mahnaz ZAREI, Mahmoud DJALALI |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Iranian Journal of Public Health, Vol 44, Iss 10 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2251-6085 2251-6093 |
| Popis: | Background: Nephrotic syndrome is a disorder that leads to hyperlipidemia. L-carnitine and genistein can effect on lipid metabolism and the syndrome. In the present study, we have delved into the separate and the twin-effects of L-carnitine and genistein on the gene expressions of HMG-COA reductase and LDL receptor in experimental nephrotic syndrome. Methods: In this controlled experimental study, 50 male Sprague–Dawley rats were randomly divided into five groups: NC (normal-control), PC (patient-control), LC (L-carnitine), G (genistein), LCG (L-carnitine-genistein). Adriamycin was used for inducing nephrotic syndrome and the spot urine samples and urine protein-to-creatinine ratio were measured. Hepatocytic RNA was extracted and real-time PCR was used for HMG-COA Reductase and LDL receptor gene Expression measurement. Results: The final weight of the patients groups were lower than the NC group (P=0.001), and weight gain of the NC group was higher than the other groups (P |
| Databáze: | Directory of Open Access Journals |
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