| Autor: |
Adhya Mehta, Amrin Kharawala, Sanjana Nagraj, Samuel J. Apple, Diego Barzallo, Majd Al Deen Alhuarrat, Cesar Joel Benites Moya, Sindhu Vikash, Panagiotis Zoumpourlis, Sophia Xesfingi, Dimitrios Varrias, Yunus Emre Demirhan, Leonidas Palaiodimos, Dimitrios Karamanis |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Journal of Respiration, Vol 3, Iss 2, Pp 39-48 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2673-527X |
| DOI: |
10.3390/jor3020005 |
| Popis: |
Hyperlipidemia has been associated with worse outcomes in patients with Coronavirus disease 2019 (COVID-19). However, lower LDL-C (low-density lipoprotein cholesterol) levels have been associated with increased COVID-19 severity and mortality. We conducted a retrospective observational study of patients with COVID-19 admitted to New York City Health and Hospitals from 1 March 2020 to 31 October 2020, comparing pre-COVID-19 LDL-C levels or LDL-C levels obtained during COVID-19 hospitalization, with the need for invasive mechanical ventilation and death. Propensity score matching was performed using logistic regression models, and standardized mean differences were calculated. A total of 3020 patients (median age 61 years; 36% women) were included. In the matched cohort, on multivariate logistic regression analysis, LDL was inversely associated with in-hospital death (OR: 0.99, 95% CI: 0.986–0.999, p = 0.036). As a categorical variable, LDL > 70 mg/dL was associated with 47% lower likelihood of invasive mechanical ventilation (OR: 0.53, 95% CI: 0.29–0.95, p = 0.034). No significant association between pre-COVID-19 LDL and death or invasive mechanical ventilation was found (OR: 1.00, 95% CI 0.99–1.01, p = 0.833). Low LDL-C level measured during COVID-19 was associated with a higher likelihood of invasive mechanical ventilation and in-hospital death. A similar association was not found between pre-COVID-19 LDL-C and these outcomes. LDL-C levels obtained during COVID-19 are likely not reflective of the baseline lipid profile. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
