Complete Clinical Remission of Stage IV Triple-Negative Breast Cancer Lung Metastasis Administering Low-Dose Immune Checkpoint Blockade in Combination With Hyperthermia and Interleukin-2
| Autor: | Ralf Kleef MD, Ralph Moss PhD, A. Marcell Szasz MD, PhD, Arthur Bohdjalian MD, Hans Bojar MD, Tibor Bakacs MD, PhD |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Integrative Cancer Therapies, Vol 17 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1534-7354 1552-695X 15347354 |
| DOI: | 10.1177/1534735418794867 |
| Popis: | The prognosis of triple-negative breast cancer with metastases after chemotherapy remains dismal. We report the case of a 50-year-old female with first disease recurrence at the axillary lymph node and, later on, bilateral pulmonary metastases with severe shortness of breath. The patient received low-dose immune checkpoint blockade (concurrent nivolumab and ipilimumab) weekly over 3 weeks with regional hyperthermia 3 times a week, followed by systemic fever-range hyperthermia induced by interleukin-2 for 5 days. She went into complete remission of her pulmonary metastases with transient WHO I-II diarrhea and skin rash. The patient remained alive for 27 months after the start of treatment, with recurrence of metastases as a sternal mass, and up to 3 cm pleural metastases. This exceptional response should instigate further research efforts with this protocol, which consists only of approved drugs and treatments. |
| Databáze: | Directory of Open Access Journals |
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