| Autor: |
F. Eckstein, S. Maschek, A. Culvenor, L. Sharma, F.W. Roemer, G.N. Duda, W. Wirth |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Osteoarthritis and Cartilage Open, Vol 5, Iss 3, Pp 100365- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2665-9131 |
| DOI: |
10.1016/j.ocarto.2023.100365 |
| Popis: |
Objective: Therapy for osteoarthritis ideally aims at preserving structure before radiographic change occurs. This study tests: a) whether longitudinal deterioration in cartilage thickness and composition (transverse relaxation-time T2) are greater in radiographically normal knees “at risk” of incident osteoarthritis than in those without risk factors; and b) which risk factors may be associated with these deteriorations. Design: 755 knees from the Osteoarthritis Initiative were studied; all were bilaterally Kellgren Lawrence grade [KLG] 0 initially, and had magnetic resonance images available at 12- and 48-month follow-up. 678 knees were “at risk”, whereas 77 were not (i.e., non-exposed reference). Cartilage thickness and composition change was determined in 16 femorotibial subregions, with deep and superficial T2 being analyzed in a subset (n = 59/52). Subregion values were used to compute location-independent change scores. Results: In KLG0 knees “at risk”, the femorotibial cartilage thinning score (−634 ± 516 μm) over 3 years exceeded the thickening score by approximately 20%, and was 27% greater (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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