| Autor: |
Marcello Moro Queiroz, Carlos Diego Holanda Lopes, Alessandra Corte Real Salgues, Felipe de Galiza Barbosa, Emerson Shigueaki Abe, Thales Parenti Silveira, Marcel Cerqueira Cesar Machado, Fernanda Cunha Capareli |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
European Journal of Hybrid Imaging, Vol 5, Iss 1, Pp 1-6 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2510-3636 |
| DOI: |
10.1186/s41824-021-00103-4 |
| Popis: |
Abstract Background Pancreatic neuroendocrine tumor (PNET) is a subgroup of neuroendocrine tumor (NET) that has unique biology and natural history. The histological classification has a major role in the management of this pathology, but in recent years Gallium 68 dotatate (68Ga-DOTA) scanning is at the center of a discussion about how these imaging technologies can modify clinical management of neuroendocrine tumors and how their results are correlated to Ki67 index. Method We hereby describe a case of a patient that investigated an unspecific stable pancreatic nodule suspected of high-grade NET after evaluation with 68Ga-DOTATOC positron emission tomography—computed tomography (PETCT) and 18F-Fluorodeoxyglucose (18F-FDG) PETCT. Results The images corroborate the hypothesis of high-grade NET based on the standard uptake value (SUV) described in both image exams (16.4 in 18FDG PETCT and 9.2 in 68Ga-DOTATOC PETCT). After surgery, the histopathological analyses revealed a localized grade 2 well-differentiated NET, Ki-67 of 4.7, glucose transport proteins 1 (GLUT1) negative by immunohistochemistry, evidencing a rare case of mismatch between the functional image and the in vivo characterization of the neoplasm. Conclusion Functional imaging of neuroendocrine tumors with different modalities of PETCT is a well-described strategy for evaluating PNET and can dictate conducts in some cases. However, histopathological analysis is crucial to confirm the grade and prognosis related to this disease. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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