| Autor: |
Prof. James A Berkley, FRCPCH, Moses Ngari, MSc, Johnstone Thitiri, MSc, Laura Mwalekwa, HND, Molline Timbwa, HND, Fauzat Hamid, HND, Rehema Ali, SRN, Jimmy Shangala, BPharm, Neema Mturi, MRCPCH, Kelsey D J Jones, MRCPCH, Hassan Alphan, BSc, Beatrice Mutai, MMed, Victor Bandika, MMed, Twahir Hemed, MMed, Ken Awuondo, MSc, Susan Morpeth, FRACP, Prof. Samuel Kariuki, PhD, Gregory Fegan, PhD |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
The Lancet Global Health, Vol 4, Iss 7, Pp e464-e473 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
2214-109X |
| DOI: |
10.1016/S2214-109X(16)30096-1 |
| Popis: |
Background: Children with complicated severe acute malnutrition (SAM) have a greatly increased risk of mortality from infections while in hospital and after discharge. In HIV-infected children, mortality and admission to hospital are prevented by daily co-trimoxazole prophylaxis, despite locally reported bacterial resistance to co-trimoxazole. We aimed to assess the efficacy of daily co-trimoxazole prophylaxis on survival in children without HIV being treated for complicated SAM. Methods: We did a multicentre, double-blind, randomised, placebo-controlled study in four hospitals in Kenya (two rural hospitals in Kilifi and Malindi, and two urban hospitals in Mombasa and Nairobi) with children aged 60 days to 59 months without HIV admitted to hospital and diagnosed with SAM. We randomly assigned eligible participants (1:1) to 6 months of either daily oral co-trimoxazole prophylaxis (given as water-dispersible tablets; 120 mg per day for age |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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