| Autor: |
Frank A. Petrigliano, Nancy Q. Liu, Siyoung Lee, Jade Tassey, Arijita Sarkar, Yucheng Lin, Liangliang Li, Yifan Yu, Dawei Geng, Jiankang Zhang, Ruzanna Shkhyan, Jacob Bogdanov, Ben Van Handel, Gabriel B. Ferguson, Youngjoo Lee, Svenja Hinderer, Kuo-Chang Tseng, Aaron Kavanaugh, J. Gage Crump, April D. Pyle, Katja Schenke-Layland, Fabrizio Billi, Liming Wang, Jay Lieberman, Mark Hurtig, Denis Evseenko |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-14 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2057-3995 |
| DOI: |
10.1038/s41536-021-00187-3 |
| Popis: |
Abstract Osteoarthritis (OA) impacts hundreds of millions of people worldwide, with those affected incurring significant physical and financial burdens. Injuries such as focal defects to the articular surface are a major contributing risk factor for the development of OA. Current cartilage repair strategies are moderately effective at reducing pain but often replace damaged tissue with biomechanically inferior fibrocartilage. Here we describe the development, transcriptomic ontogenetic characterization and quality assessment at the single cell level, as well as the scaled manufacturing of an allogeneic human pluripotent stem cell-derived articular chondrocyte formulation that exhibits long-term functional repair of porcine articular cartilage. These results define a new potential clinical paradigm for articular cartilage repair and mitigation of the associated risk of OA. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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