11C-CFT PET brain imaging in Parkinson’s disease using a total-body PET/CT scanner

Autor: Xiaolin Sun, Xiaoyue Tan, Qing Zhang, Shanzhen He, Siyun Wang, Yongrong Zhou, Qi Huang, Lei Jiang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: EJNMMI Physics, Vol 11, Iss 1, Pp 1-11 (2024)
Druh dokumentu: article
ISSN: 2197-7364
DOI: 10.1186/s40658-024-00640-4
Popis: Abstract Purpose This study aimed to evaluate the feasibility of 11C-CFT PET brain imaging in Parkinson’s Disease using a total-body PET/CT scanner and explore the optimal scan duration to guide the clinical practice. Methods Thirty-two patients with Parkinson’s disease (PD) performing 11C-CFT PET/CT brain imaging using a total-body PET/CT scanner were retrospectively enrolled. The PET data acquired over a period of 900 s were reconstructed into groups of different durations: 900-s, 720-s, 600-s, 480-s, 300-s, 180-s, 120-s, 60-s, and 30-s (G900 to G30). The subjective image quality analysis was performed using 5-point scales. Semi-quantitative measurements were analyzed by SUVmean and dopamine transporter (DAT) binding of key brain regions implicated in PD, including the caudate nucleus and putamen. The full-time images (G900) were served as reference. Results The overall G900, G720, and G600 image quality scores were 5.0 ± 0.0, 5.0 ± 0.0, and 4.9 ± 0.3 points, respectively, and there was no significant difference among these groups (P > 0.05). A significant decrease in these scores at durations shorter than 600 s was observed when compared to G900 images (P
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje