Maternal age and the risk of adverse pregnancy outcomes: a retrospective cohort study

Autor: Ambrogio P. Londero, Emma Rossetti, Carla Pittini, Angelo Cagnacci, Lorenza Driul
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: BMC Pregnancy and Childbirth, Vol 19, Iss 1, Pp 1-10 (2019)
Druh dokumentu: article
ISSN: 1471-2393
DOI: 10.1186/s12884-019-2400-x
Popis: Abstract Background The increased potential for negative pregnancy outcomes in both extremes of reproductive age is a well-debated argument. The aim of this study was to analyze the prevalence and the outcome of pregnancies conceived at extreme maternal ages. Methods This retrospective study considered all single consecutive pregnancies delivered in a tertiary referral center between 2001 and 2014. Patients were categorized into 4 groups according to maternal age at delivery ( 40 years). The following outcomes were considered (amongst others): pregnancy-related hypertensive disorders (PRHDs), neonatal resuscitation (NR), neonatal intensive care unit (NICU) admission, periventricular leucomalacia (PVL), and grade 3 and 4 intraventicular hemorrhage (IVH). Results During the considered period 22,933 single pregnancies gave birth in our unit. We observed 71 women aged 40 years. In each year throughout the study period, there was a significant increment in maternal age of 0.041 years (95% CI 0.024–0.058) every new year. Multivariate analysis concluded out that maternal age over 40 years was an independent risk factor for preterm delivery (OR 1.36 95% CI 1.16–1.61, p
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