Risk of Active Tuberculosis During Anti-TNF-α Inhibitor Use to Treat Rheumatoid Arthritis: A Meta-Analysis of Randomized Controlled Trials
| Autor: | Hanxin Wu, Li Peng, Weijie Ma, Liangyu Zhu, Xinya Wu, Li Gao, Lei Zhong, Jieqin Song, Bingxue Li, Xun Huang, Rui Yang, Fukai Bao, Aihua Liu |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | International Journal of Biomedicine, Vol 14, Iss 3, Pp 371-378 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2158-0510 2158-0529 |
| DOI: | 10.21103/Article14(3)_RA1 |
| Popis: | Background: Given the wide application of TNF-α inhibitors for the treatment of rheumatoid arthritis (RA), more active tuberculosis cases have been reported in patients with RA. This meta-analysis was performed to evaluate the risk of active tuberculosis (TB) in RA patients undergoing treatment with TNF-α inhibitors. Methods and Results: Thirty randomized controlled trials (RCTs), comprising 18,640 patients, were included in the meta-analysis after searching PubMed, EMBASE, and Web of Science databases. Overall, there was a higher risk of active TB in patients with RA undergoing treatment with TNF-α inhibitors than in the control group (Peto OR, 2.57; 95%CI, 1.42-4.66; P=0.002). Conclusion: Our meta-analysis showed that RA patients treated with TNF-α inhibitors had a higher risk of developing active TB. Tuberculosis screening should be performed before and during the use of TNF-α inhibitors in these patients. |
| Databáze: | Directory of Open Access Journals |
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