Is the function of the HBeAg really unknown?

Autor:	David R. Milich
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	hepatitis b virus hbeag hbv vaccine immune tolerance chronicity Immunologic diseases. Allergy RC581-607 Therapeutics. Pharmacology RM1-950
Zdroj:	Human Vaccines & Immunotherapeutics, Vol 15, Iss 9, Pp 2187-2191 (2019)
Druh dokumentu:	article
ISSN:	2164-5515 2164-554X 21645515
DOI:	10.1080/21645515.2019.1607132
Popis:	The immune response to the hepatitis B virus (HBV) vaccine in newborns of hepatitis B e antigen (HBeAg)-positive or HBeAg-negative mothers is the subject of Huang et al. The authors report no correlation between the HBeAg status of the mothers/cord blood and the newborns immune response to the vaccine, but, unfortunately, draw unfounded conclusions regarding the tolerogenic potential of in utero exposure to HBeAg. In this reply, I address the possible influence of in utero exposure to the HBeAg, and briefly review other characteristics of the HBeAg, that may promote HBV chronicity. I argue that the function of HBeAg should no longer be considered “unknown” and that immunotolerance/immunomodulation represent the dominant functions of the HBeAg in viral–host interactions.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/b8e3c378251f4340b6ccf3b33516a575 Zobrazit plný text záznamu View record in DOAJ