| Autor: |
Tsompos Constantinos, Panoulis Constantinos, Toutouzas Konstantinos, Zografos George, Papalois Apostolos |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Folia Medica, Vol 57, Iss 3-4, Pp 235-242 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1314-2143 |
| DOI: |
10.1515/folmed-2015-0044 |
| Popis: |
The AIM of this experimental study was to evaluate the effect of the antioxidant drug “U-74389G” in a rat model of hypoxia reoxygenation (HR) using the previously established protocol. Effects of treatment were evaluated by mean red blood cell distribution width (RDW) levels. MATERIALS AND METHODS: 40 rats of a mean weight of 231.875 g were employed in the study. RDW levels were determined at 60 min (groups A and C) and at 120 min (groups B and D) after starting the reoxygenation. Groups A and B received no drugs, whereas rats from groups C and D were administered with U-74389G. RESULTS: demonstrated that U-74389G administration significantly decreased the RDW levels by 4.96% + 2.27% (p = 0.0175). Reoxygenation time non-significantly decreased the RDW levels by 0.27% + 2.41% (p = 0.8889). Together, U-74389G administration and reoxygenation time non-significantly decreased the RDW levels by 2.54% + 1.39% (p = 0.0679). CONCLUSIONS: U-74389G administration particulary in concert without reperfusion declines the RDW levels even within the short - time context of 1.5 hours reperfusion. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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