| Autor: |
Caio César Chaves Costa, Nathalia Gabay Pereira, Anna Luiza Melo Machado, Mariana Albuquerque Dórea, Rafaella Macêdo Monteiro da Cruz, Renata Cunha Silva, Robson José de Souza Domingues, Edson Yuzur Yasojima |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Acta Cirúrgica Brasileira, Vol 34, Iss 7 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
0102-8650 |
| DOI: |
10.1590/s0102-865020190070000007 |
| Popis: |
Abstract Purpose: To evaluate the effects of splenic ischemic preconditioning (sIPC) on oxidative stress induced by hepatic ischemia-reperfusion in rats. Methods: Fifteen male Wistar rats were equally divided into 3 groups: SHAM, IRI and sIPC. Animals from IRI group were subjected to 45 minutes of partial liver ischemia (70%). In the sIPC group, splenic artery was clamped in 2 cycles of 5 min of ischemia and 5 min of reperfusion (20 min total) prior to hepatic ischemia. SHAM group underwent the same surgical procedures as in the remaining groups, but no liver ischemia or sIPC were induced. After 1h, hepatic and splenic tissue samples were harvested for TBARS, CAT, GPx and GSH-Rd measurement. Results: sIPC treatment significantly decreased both hepatic and splenic levels of TBARS when compared to IRI group (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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