| Autor: |
WU Lili, ZHANG Yixin, LIU Hao, WU Di, QIN Lin, TAN Daopeng, LU Yanliu, PENG Jie |
| Jazyk: |
čínština |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Zhongguo shipin weisheng zazhi, Vol 36, Iss 3, Pp 253-259 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1004-8456 |
| DOI: |
10.13590/j.cjfh.2024.03.003 |
| Popis: |
ObjectiveTo determine the effects of Dendrobium nobile Lindl. on the regulation of lipid metabolism based on metabolomics.MethodsTwenty-four rats were randomly divided into the normal control and D. nobile treatment （0.25 g/kg） groups. Rats were intragastrically administered their assigned treatment once every 6 h for 5 d. After the last treatment， the plasma and liver of the animals were collected. Metabolomics were evaluated using UPLC-MS. Principal component analysis （PCA）， cluster analysis， and KEGG pathway analysis were performed to assess the metabolomics data. Compared with the normal control group， different metabolites were identified in the D. nobile treatment group. The expression levels of lipid metabolism-related genes were validated using quantitative real-time PCR.ResultsObvious differences were found between the normal control group and D. nobile treatment group， with significant differences obtained for 1 448 metabolites （P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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