| Autor: |
Xin-Hua Xiao, Xiao-Yan Qi, Jiao-Yang Li, Yi-Bing Wang, Ya-Di Wang, Zhe-Zhen Liao, Jing Yang, Li Ran, Ge-Bo Wen, Jiang-Hua Liu |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
BMC Endocrine Disorders, Vol 19, Iss 1, Pp 1-6 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1472-6823 |
| DOI: |
10.1186/s12902-019-0336-9 |
| Popis: |
Abstract Background Zinc-α2-glycoprotein (ZAG) is a recently novel lipolytic adipokine implicated in regulation of glucose and lipid metabolism in many metabolic disorders. In vitro and animal studies suggest that thyroid hormones (TH) up-regulates ZAG production in hepatocytes. However, there is no data evaluating the possible relationship between ZAG and TH in a human model of hyperthyroidism. The objective of the present study is to assess the association of serum ZAG levels with TH and lipid profile in patients with hyperthyroidism before and after methimazole treatment. Methods A total of 120 newly diagnosed overt hyperthyroidism and 122 healthy control subjects were recruited. Of them, 39 hyperthyroidism patients were assigned to receive methimazole treatment as follow-up study for 2 months. Results The clinical consequence showed that serum ZAG levels were elevated in patients with hyperthyroidism (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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