| Autor: |
Kristine Mørk Kindberg, MD, Kaspar Broch, MD, PhD, Geir Øystein Andersen, MD, PhD, Anne Kristine Anstensrud, MD, Sissel Åkra, MSc, Sindre Woxholt, MD, Ingvild Maria Tøllefsen, MD, PhD, Thor Ueland, PhD, Brage Høyem Amundsen, MD, PhD, Nils-Einar Kløw, MD, PhD, Bente Halvorsen, MSc, PhD, Tuva B. Dahl, MSc, PhD, Camilla Huse, PhD, Sarah Louise Murphy, MSc, Jan Kristian Damås, MD, PhD, Anders Opdahl, MD, PhD, Rune Wiseth, MD, PhD, Lars Gullestad, MD, PhD, Pål Aukrust, MD, PhD, Carlos Santos-Gallego, MD, Ingebjørg Seljeflot, PhD, Mathis Korseberg Stokke, MD, PhD, Ragnhild Helseth, MD, PhD |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
JACC: Advances, Vol 3, Iss 9, Pp 101193- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2772-963X |
| DOI: |
10.1016/j.jacadv.2024.101193 |
| Popis: |
Background: Interleukin-6-receptor inhibition with tocilizumab improves myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI). Reduced levels of neutrophil extracellular traps (NETs), which consist of nuclear material studded with proteins released upon neutrophil activation, might contribute to this effect. Objectives: The purpose of this study was to evaluate the effect of tocilizumab on NETs and investigate the association between NETs and myocardial injury in patients with STEMI. Methods: In the ASSAIL-MI study, 199 patients with STEMI were randomized to tocilizumab or placebo during percutaneous coronary intervention. In this substudy, we analyzed blood levels of the NET markers double-stranded deoxyribonucleic acid (dsDNA), myeloperoxidase-DNA, and citrullinated histone 3 (H3Cit) at admission and after 24 hours and 3 to 7 days. In a subgroup of patients, we assessed regulation of transcripts related to the formation of NETs. We also investigated associations between NET markers and the myocardial salvage index (MSI). Results: All NET markers were lower in the tocilizumab group than in the placebo group at 3 to 7 days (all P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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