| Autor: |
Daiki Shimomura, Yoshihisa Nakagawa, MD, Hirokazu Kondo, MD, Toshihiro Tamura, MD, Masashi Amano, MD, Yukiko Hayama, MD, Naoaki Onishi, MD, Yodo Tamaki, MD, Makoto Miyake, MD, Kazuaki Kaitani, MD, Chisato Izumi, MD, Masahiko Hayashida, Aya Fukuda, Fumihiko Nakamura, MD, Seiji Kawano, MD |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Journal of Arrhythmia, Vol 31, Iss 4, Pp 183-188 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1880-4276 |
| DOI: |
10.1016/j.joa.2014.11.003 |
| Popis: |
Background: Activated partial thromboplastin time (aPTT) is recommended for monitoring anticoagulant activity in dabigatran-treated patients; however, there are limited data in Japanese patients. To clarify the relationship between plasma dabigatran concentration and aPTT, we analyzed plasma dabigatran concentration and aPTT at various time points following administration of oral dabigatran in a Japanese hospital. Methods: We enrolled 149 patients (316 blood samples) with non-valvular atrial fibrillation (NVAF) who were taking dabigatran. Patients had a mean age of 66.6±10.0 years (range: 35–84) and 66% were men. Plasma dabigatran concentrations and aPTT were measured using the Hemoclot® direct thrombin inhibitor assay and Thrombocheck aPTT-SLA®, respectively. Samples were classified into eight groups according to elapsed times in hours since oral administration of dabigatran. Results: Significantly higher dabigatran concentrations were observed in samples obtained from patients with low creatinine clearance (CLCr) (CLCr |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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