Impact of fluconazole versus posaconazole prophylaxis on the incidence of fungal infections in patients receiving induction chemotherapy for acute myeloid leukemia

Autor: Camille Devanlay, Emmanuelle Tavernier-Tardy, Aurélie Bourmaud, Alexander Tuan Falk, Hélène Raberin, Sandrine Menguy, Denis Guyotat, Nicolas Magné, Jérôme Cornillon
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Biomedical Journal, Vol 38, Iss 3, Pp 235-243 (2015)
Druh dokumentu: article
ISSN: 2319-4170
2320-2890
DOI: 10.4103/2319-4170.143491
Popis: Background: Invasive fungal infections (IFIs) remain one of the worrying complications in patients with acute myeloid leukemia (AML) due to their incidence and high level of attributable mortality. In light of these risks, antifungal prophylaxis has always been debated. We conducted a single-center retrospective study of two prophylactic antifungal agents (fluconazole/posaconazole) in 91 consecutive patients receiving induction chemotherapy for AML between 2005 and 2009, in order to evaluate the impact on the incidence of IFI and on the mycological flora of the patients. Methods: In total, 39 patients received prophylactic fluconazole versus 52 who received posaconazole. The baseline characteristics of the two groups were comparable. Results: Overall, 17 patients developed an IFI, with no difference in frequency between the two groups. Utilization of empirical or pre-emptive therapy was similar irrespective of the type of prophylaxis used. Mycological examination of stools revealed an increase in non-albicans Candida colonization in the fluconazole group during hospitalization and the appearance of Saccharomyces cerevisiae colonization in patients receiving posaconazole. Conclusion: The present study does not distinguish between fluconazole and posaconazole as a primary effective prevention against fungal infections. More prospective studies and meta-analyses are warranted.
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