| Autor: |
Rasha A. Al-Lami, M.D., M.S.-C.S., Shaden A. Taha, M.S., Randa J. Jalloul, M.D., Hugh S. Taylor, M.D. |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
F&S Reports, Vol 3, Iss 1, Pp 63-70 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2666-3341 |
| DOI: |
10.1016/j.xfre.2021.12.003 |
| Popis: |
Objective: To study the association between high-sensitivity C-reactive protein (hs-CRP) and infertility among reproductive-age women while controlling for obesity and other metabolic markers. Previous studies found a link between infertility and cardiovascular diseases (CVDs). C-reactive protein is a sensitive marker of CVDs, and its levels are affected by obesity. Design/Setting: We conducted a cross-sectional study using national data from 2015 through 2018. Patients: A total of 940 women aged 20–45 years who self-reported infertility, had hs-CRP values measured, and did not have CRP >10 mg/L, asthma, arthritis, bronchitis, thyroid disease, bilateral oophorectomy, hysterectomy, and who were not breastfeeding or pregnant, premenarchal at the time of study or had menarche after the age of 20. Interventions: N/A. Main outcome measure(s): Infertility status (ever reporting inability to conceive with 12 months of trying to become pregnant). Results: In comparison to noninfertile women, self-reported infertile women had higher mean of hs-CRP (3.11 mg/L vs. 2.40 mg/L) and higher percentage of moderate/high hs-CRP values (77.0% vs 58.8%). However, after adjusting for metabolic markers, there was a nonsignificant association between moderate/high hs-CRP and self-reported infertility in the multivariable logistic regression analysis. Odds ratio estimates of the association between hs-CRP and infertility increased over 40% after removing obesity measures and/or high-density lipoprotein from regression models. Conclusion: There was no association between hs-CRP and self-reported infertility after controlling for obesity measures and other risk factors for CVDs in a sample of U.S. women aged 20–45 years. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
