First study of hepatitis delta virus in Algeria: Seroprevalence and risk factors in Setif region (east of Algeria)

Autor: Abdelkader Gasmi, Wahiba Guenifi, Amel Ouyahia, Mounira Rais, Houda Boukhrissa, Abderahmen Hachani, Salah Mechakra, Slimen Laouamri, Abderezak Touabti, Abdelmadjid Lacheheb
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Southern African Journal of Infectious Diseases, Vol 34, Iss 1, Pp e1-e6 (2019)
Druh dokumentu: article
ISSN: 2312-0053
2313-1810
DOI: 10.4102/sajid.v34i1.110
Popis: Background: No recent data are available on hepatitis delta virus (HDV) prevalence in Algeria. For this reason we conducted an epidemiological study, cross-sectional seroprevalence of HDV in the region of Setif. Methods: Between 2011 and 2014, sera samples of 500 patients (carrying HBsAg) admitted to the Division of Infectious Diseases Teaching Hospital, Setif (east of Algeria), were tested for anti-HDV-IgG ab (ETI-AB-DeltaK-2). Results: The prevalence of HDV obtained is estimated at 2.4%. The prevalence ranges from 1% in chronic hepatitis to 11.1% in cirrhotic hepatitis (low endemic area). Seropositivity rate is closely correlated with age (Odds ratio [OR] = 9.98, p = 0.000) and gender (OR = 0.24, p = 0.025); it reaches 58.3% in the age group of 51–60 years and 0% in children (age group 1–15 years); it represents 75% in females and 25% in males. The presence of familial cases of HBsAg positive (OR = 4.54, p = 0.006), the endoscopic procedure (OR = 6.54, p = 0.000) and tattooing (OR = 20, p = 0.000) were found to be the transmission risk factors. A statistically significant relationship was found between the positivity of anti-HDV and advanced liver disease, cirrhosis (OR = 9. 16, p = 0.000). A significant correlation was found between the positivity of anti-HDV with diabetes (OR = 6.83, p = 0.000), obesity (OR = 4.19, p = 0.009) and viral suppression B (OR = 5.69, p = 0.003). Conclusion: Our results show that HDV infection is low in Algeria. Research for total anti-HDV should be part of the initial assessment of patient care with viral hepatitis B as well as the prevalence of other viruses (hepatitis C [HCV] and HIV). A multicentre study should be carried out to know the importance of HDV infection and identify the risk groups.
Databáze: Directory of Open Access Journals
Externí odkaz: