| Autor: |
Corey J. Bolton, Omair A. Khan, Dandan Liu, Sydney Wilhoite, Logan Dumitrescu, Amalia Peterson, Kaj Blennow, Henrik Zetterberg, Timothy J. Hohman, Angela L. Jefferson, Katherine A. Gifford |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Annals of Clinical and Translational Neurology, Vol 11, Iss 11, Pp 2977-2986 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2328-9503 |
| DOI: |
10.1002/acn3.52209 |
| Popis: |
Abstract Objective This study examined the effect of cognitive status, education, and sex on the association between subjective cognitive decline (SCD) and Alzheimer's disease (AD) biomarkers in non‐demented older adults. Methods Vanderbilt Memory and Aging Project participants (n = 129), dementia or stroke free, completed fasting lumbar puncture, SCD assessment, and cognitive assessment. Cerebrospinal fluid (CSF) biomarkers for AD were analyzed. Linear regression models related SCD to CSF AD biomarkers and follow‐up models assessed interactions of SCD × cognitive status, sex, reading level, and education on AD biomarkers. Results In main effect models, higher SCD was associated with more amyloidosis (p‐values 0.38). SCD score interacted with cognitive status (p 0.51) though SCD related to amyloid markers in the higher reading‐level group (p‐values |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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