| Autor: |
Jovana Petkovska, Nikola Geskovski, Darka Marković, Vesna Dimova, Dejan Mirakovski, Maja Radetić, Igor Jordanov |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Carbohydrate Polymer Technologies and Applications, Vol 7, Iss , Pp 100438- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2666-8939 |
| DOI: |
10.1016/j.carpta.2024.100438 |
| Popis: |
Environmentally benign pH-indicating wound dressing comprised of carbohydrates chitosan (CH) and pectin (P), and anthocyanin grape (AG) dye is created via layer-by-layer assembly. Cotton fabric coated with eight bilayers of (CH-AG)4/(P-AG)4 deposited 1.97 % AG-dye. It exhibited a visible and immediate color change from pink to violet-blue while increasing its pH value from 6 to pH 7, matching the turning pH point of healing into an infected wound. Color transition of AG-dye in water-based buffers, tested by VIS-spectroscopy, shows the same color change when the pH value increased from 6 to 7. This coating imparts excellent antimicrobial activity against Gram-positive bacteria Staphylococcus aureus and yeast Candida albicans, moderate antibacterial activity against Gram-negative Escherichia coli bacteria, and no cytotoxicity on human fibroblast cells (MRC-5). This research proposes a sustainable, low-cost, and simple method for obtaining smart wound dressing that provides real-time monitoring of the wound pH. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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