Dynamic Detection of Monocyte Subsets in Peripheral Blood of Patients with Acute Hypertriglyceridemic Pancreatitis

Autor: Junyuan Zheng, Junjie Fan, Chunlan Huang, Yingying Lu, Zehua Huang, Xingpeng Wang, Yue Zeng
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Gastroenterology Research and Practice, Vol 2019 (2019)
Druh dokumentu: article
ISSN: 1687-6121
1687-630X
DOI: 10.1155/2019/5705782
Popis: Aim. Monocytes play an important role in acute pancreatitis (AP). Hypertriglyceridemic pancreatitis (HTGP) is always more severe than normal lipid-AP, whether the mechanism of aggravation involves monocyte subsets remains unknown though. The present study was aimed to analyze changes of peripheral blood M1 and M2 monocytes in HTGP patients. Methods. A total of 90 subjects were enrolled, among which 16 diagnosed with HTGP, 34 with acute biliary pancreatitis (ABP), 20 with hypertriglyceridemia (HTG), and 20 healthy controls (HC). Peripheral blood CD14+CD86+ M1 and CD14+CD206+ M2 monocytes were examined by flow cytometry on days 1, 3, and 7 after admission. Results. We found a marked increase in total and M1 monocyte count in AP patients (P
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