| Autor: |
Samuel J. Martínez-Domínguez, Sandra García-Mateo, Pilar Sainz-Arnal, Javier Martínez-García, Beatriz Gallego-Llera, María Jesús Lozano-Limones, Sandra Hidalgo, Carla J. Gargallo-Puyuelo, Marta Latre-Santos, Maria Mercedes Lourdes Nocito-Colon, Luis Martínez-Lostao, Engy Refaie, Maria Teresa Arroyo-Villarino, Marcela del Rio-Nechaevsky, Ariel Ramirez-Labrada, Julián Pardo, Fernando Gomollón, Pedro M. Baptista |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-023-50537-y |
| Popis: |
Abstract Suboptimal vaccine response is a significant concern in patients with Inflammatory Bowel Disease (IBD) receiving biologic drugs. This single-center observational study involved 754 patients with IBD. In Phase I (October 2020-April 2021), 754 IBD participants who had not previously received the SARS-CoV-2 vaccine, underwent blood extraction to assess the seroprevalence of SARS-CoV-2 infection and IBD-related factors. Phase II (May 2021-October 2021) included a subgroup of 52 IBD participants with confirmed previous SARS-CoV-2 infection, who were studied for humoral and cellular response to the SARS-CoV-2 vaccine. In Phase I, treatment with anti-TNF was associated with lower rates of seroconversion (aOR 0.25 95% CI [0.10–0.61]). In Phase II, a significant increase in post-vaccination IgG levels was observed regardless of biologic treatment. However, patients treated with anti-TNF exhibited significantly lower IgG levels compared to those without IBD therapy (5.32 ± 2.47 vs. 7.99 ± 2.59 U/ml, p = 0.042). Following vaccination, a lymphocyte, monocyte, and NK cell activation pattern was observed, with no significant differences between patients receiving biologic drugs and those without IBD treatment. Despite lower seroprevalence and humoral response to the SARS-CoV-2 vaccine in patients treated with anti-TNF, the cellular response to the vaccine did not differ significantly from that patients without IBD therapy. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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