| Autor: |
Doan C. Nguyen, Celia Saney, Ian T. Hentenaar, Monica Cabrera-Mora, Violeta Capric, Matthew C. Woodruff, Joel Andrews, Sagar Lonial, Ignacio Sanz, F. Eun-Hyung Lee |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-024-53977-2 |
| Popis: |
Abstract Following infection or vaccination, early-minted antibody secreting cells (ASC) or plasmablasts appear in circulation transiently, and a small fraction migrates to the spleen or bone marrow (BM) to mature into long-lived plasma cells (LLPC). While LLPC, by definition, are quiescent or non-dividing, the majority of blood ASC are thought to be “blasting” or proliferative. In this study, we find > 95% nascent blood ASC in culture express Ki-67 but only 6–12% incorporate BrdU after 4 h or 24 h labeling. In contrast, |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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