Enantioselective alkylative cross-coupling of unactivated aromatic C–O electrophiles

Autor: Zishuo Zhang, Jintong Zhang, Quan Gao, Yu Zhou, Mingyu Yang, Haiqun Cao, Tingting Sun, Gen Luo, Zhi-Chao Cao
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-30693-x
Popis: Transition-metal catalyzed alkylative cross-couplings are established, powerful tools for the installation of alkyl groups. Here, the authors unlock a C(sp3)–C(sp2) cross-coupling via the asymmetric activation of the aromatic C–O bond by bis-ligated nickel complexes for the synthesis of alkylated, axially chiral biaryl compounds.
Databáze: Directory of Open Access Journals