Total neoadjuvant therapy in rectal cancer: a review across studies

Autor:	Gavalas Ioannis, Trichas Miltiadis, Emmanouilides Christos
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	rectal cancer total neoadjuvant therapy phase iii studies induction consolidation organ preservation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Forum of Clinical Oncology, Vol 14, Iss 2, Pp 7-14 (2024)
Druh dokumentu:	article
ISSN:	1792-362X
DOI:	10.2478/fco-2023-0014
Popis:	The optimal management of locally advanced rectal cancer (LARC) often presents a therapeutic challenge. Balancing the benefits of treatment against toxicities and reducing the risk for local and distal recurrences are the mainstay of therapeutic approaches. Recently, several studies have compared a more aggressive approach of delivering several cycles of systemic chemotherapy to the established standard of combined chemoradiation. This approach is termed total neoadjuvant therapy and appears to be beneficial, at least for a subset of patients. The results of the main Phase III studies along with their variations in study design are hereby discussed with the goal of extracting useful clinical suggestions for treatment.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/b7f3b10abfa34b46a3cbbc9ef2bd181e Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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