| Autor: |
Azadeh Hamedi, Mohammad M. Zarshenas, Akram Jamshidzadeh, Saeed Ahmadi, Reza Heidari, Ardalan Pasdaran |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Trends in Pharmaceutical Sciences, Vol 5, Iss 3, Pp 153-164 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2423-5652 |
| DOI: |
10.30476/tips.2019.82996.1020 |
| Popis: |
The present investigation was carried out to evaluate the pharmacognostic properties of Citrus aurantium seeds as well as its anti-inflammatory activities. The n-hexane fraction of seed oil extracted via a Soxhlet extractor and subjected to pharmacognostic assays, HPTLC and GC-MS analysis for determination of fatty acids and sterols. The possible anti-inflammatory and antinociceptive activities in rats were evaluated using formalin-induced paw licking, oedema and myeloperoxidase activity assessment. Total ash, acid insoluble and water soluble ash values were determined as 35.83 ± 4.92, 6.67 ± 2.89 and 28.33 ± 5.77 mg/g, respectively. HPTLC assessment revealed the presence of different fatty acids and steroidal triterpenes. The principal fatty acids of the seed oil were linoleic acid (C18:2, 50.10 ± 2.58 %) and Oleic acid (C18:1, 30.14 ± 0.39). Esterified (2.40 mg/g) and free β-sitosterol (32.90 mg/g), free campesterol (3.9 mg/g) and free stigmasterol (10.165 mg/g) were detected in the oil. Seed oil exhibited anti-inflammatory properties in the first and the second phases of formalin test. Also, it had anti-edematogenic effects but exerted no effects on myeloperoxidase activity. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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