Effect of cyclosporin-A on the blood–retinal barrier permeability in streptozotocin-induced diabetes

Autor: Anália Carmo, José G. Cunha-Vaz, Arsélio P. Carvalho, Maria Celeste Lopes
Jazyk: angličtina
Rok vydání: 2000
Předmět:
Zdroj: Mediators of Inflammation, Vol 9, Iss 5, Pp 243-248 (2000)
Druh dokumentu: article
ISSN: 0962-9351
1466-1861
09137408
DOI: 10.1080/09629350020025764
Popis: Background: Our previous results showed that in retinas from streptozotocin (STZ)-induced diabetic rats there is an increased level of interleukin-1β (IL-1β ). This cytokine may be involved in the expression of the inducible isoform of the nitric oxide synthase (iNOS), with consequent synthesis of large amounts of NO and blood–retinal barrier (BRB) breakdown.
Databáze: Directory of Open Access Journals
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