Drug Combinations as a First Line of Defense against Coronaviruses and Other Emerging Viruses

Autor: Judith M. White, Joshua T. Schiffer, Rachel A. Bender Ignacio, Shuang Xu, Denis Kainov, Aleksandr Ianevski, Tero Aittokallio, Matthew Frieman, Gene G. Olinger, Stephen J. Polyak
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: mBio, Vol 12, Iss 6 (2021)
Druh dokumentu: article
ISSN: 2150-7511
DOI: 10.1128/mbio.03347-21
Popis: ABSTRACT The world was unprepared for coronavirus disease 2019 (COVID-19) and remains ill-equipped for future pandemics. While unprecedented strides have been made developing vaccines and treatments for COVID-19, there remains a need for highly effective and widely available regimens for ambulatory use for novel coronaviruses and other viral pathogens. We posit that a priority is to develop pan-family drug cocktails to enhance potency, limit toxicity, and avoid drug resistance. We urge cocktail development for all viruses with pandemic potential both in the short term (
Databáze: Directory of Open Access Journals