| Autor: |
Alba Torres-Valle, Larraitz Aragon, Susana L. Silva, Cristina Serrano, Miguel Marcos, Josefa Melero, Carolien Bonroy, Pedro Pablo Arenas-Caro, David Monzon Casado, Pedro Mikel Requejo Olaizola, Jana Neirinck, Mattias Hofmans, Sonia de Arriba, María Jara, Carlos Prieto, Ana E. Sousa, Álvaro Prada, Jacques J. M. van Dongen, Martín Pérez-Andrés, Alberto Orfao |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Frontiers in Immunology, Vol 14 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1664-3224 |
| DOI: |
10.3389/fimmu.2023.1285088 |
| Popis: |
IntroductionGood syndrome (GS) is a rare adult-onset immunodeficiency first described in 1954. It is characterized by the coexistence of a thymoma and hypogammaglobulinemia, associated with an increased susceptibility to infections and autoimmunity. The classification and management of GS has been long hampered by the lack of data about the underlying immune alterations, a controversy existing on whether it is a unique diagnostic entity vs. a subtype of Common Variable Immune Deficiency (CVID).MethodsHere, we used high-sensitive flow cytometry to investigate the distribution of up to 70 different immune cell populations in blood of GS patients (n=9) compared to age-matched CVID patients (n=55) and healthy donors (n=61).ResultsAll 9 GS patients displayed reduced B-cell counts -down to undetectable levels ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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