| Autor: |
O. Oyeyemi, C. Ezekiel, K. Ayeni, W. Nabofa, I. Oyeyemi, O. Oyedele, A. Adefalujo, C. Nwozichi, A. Dada |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
African Journal of Urology, Vol 24, Iss 2, Pp 152-156 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1110-5704 |
| DOI: |
10.1016/j.afju.2018.02.003 |
| Popis: |
Objective: To correlate the levels of bladder tumour antigen (BTA) with aflatoxin M1 (AFM) in a human population in Nigeria. Subjects and methods: A pilot, observational study was conducted with 22 human subjects randomly recruited from a Nigerian rural community. Serum and first morning urine of participants were analysed for human BTA and AFM1, respectively, using quantitative ELISA assays. Results: All the subjects were positive to AFM1 (mean = 0.235 ± 0.072 ng/mL) while 19 were positive to BTA (mean = 2.340 ± 1.741 ng/mL). A negative relationship occurred between human BTA and AFM level (r = −0.239; P = 0.285). Human BTA (2.86 ± 2.43 ng/mL; P = 0.306) and AFM1 (0.258 ± 0.065 ng/mL; P = 0.643) were higher in subjects 1–20 years. The two biomarkers were not also associated with sexes of the participants (P > 0.05), although they were higher in the female subjects. Conclusion: This study showed that there may not be a connection between aflatoxin exposure and human BTA which is one of the biomarkers of bladder cancer. Keywords: Bladder tumor antigen, Aflatoxin M1, Association, Bladder cancer pathophysiology, Nigeria |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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