| Autor: |
Mohammad Nasir Uddin, Sayeda Samina Ahmed, Monir Uzzaman, Md. Nazmul Hassan Knock, Wahhida Shumi, Abul Fazal Md. Sanaullah, Md. Mosharef Hossain Bhuyain |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Results in Chemistry, Vol 4, Iss , Pp 100329- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2211-7156 |
| DOI: |
10.1016/j.rechem.2022.100329 |
| Popis: |
This work presented the microwave assisted synthesis of six new 2́-hydroxychalcones and their characterization based on FTIR, UV–Vis, 1H NMR, and mass spectral analysis. Quantum chemical studies confirmed the structures of prepared chalcones. Antioxidant, in vitro antimicrobial and in silico antiviral studies have been performed to evaluate their biological performance. Results of molecular docking of prepared 2́-hydroxychalcones against SARS-CoV-2 (7BQY) main protease disclosed their inhibition which is comparable to standard, remdesivir and better than hydroxychloroquine (HCQ). ADMET prediction revealed them to be non-carcinogenic and relatively safe. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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