| Autor: |
Hang Li |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Engineering Microbiology, Vol 3, Iss 2, Pp 100080- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2667-3703 |
| DOI: |
10.1016/j.engmic.2023.100080 |
| Popis: |
Biosynthetic pathways without any identifiable core enzymes may encode unknown (biosynthetic route)–unknown (molecular structure) natural products. However, bioinformatics-guided mining for such unknown-unknown metabolites is challenging. Recently, an unknown-unknown biosynthetic route has been deciphered in fungi. It was found that a class of enzymes previously annotated as hypothetical proteins catalyze the biosynthesis of arginine-containing cyclodipeptides (CDPs). This advances the understanding of the biosynthesis of CDPs and highlights the vast potential of unknown-unknown natural products encoded by microbial genomes. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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