Expression and Significance of Monocarboxylate Transporters in Cortex of Rats After Exercise-induced Fatigue

Autor: GAO Chen, WANG Wan, LI Yurong, PEI Wenjuan
Jazyk: čínština
Rok vydání: 2022
Předmět:
Zdroj: Shiyan dongwu yu bijiao yixue, Vol 42, Iss 1, Pp 42-47 (2022)
Druh dokumentu: article
ISSN: 1674-5817
DOI: 10.12300/j.issn.1674-5817.2021-053
Popis: ObjectiveTo explore the correlation between the adaptation of the body to exercise-induced fatigue and the expression of monocarboxylate transporters (MCTs) in the cerebral cortex.MethodsA total of 42 SD rats were randomly divided into control group and fatigue group 1 to 6. Firstly, the average exhaustive times in each fatigue group were recorded to determine the trend of exercise-induced fatigue after 1, 3, 5, 7, 9 and 14 days exhaustive load treadmill exercises respectively. Subsequently, the changes of MCT1, MCT2 and MCT4 expression in cerebral motor cortex of rat brain were detected by Western blotting and double-labeling immunofluorescence.ResultsAfter 5 days of exercise, the average exhaustive time of rats in fatigue of group 3 reached the lowest level [(67.00±7.07) min] and it recovered to (89.17±9.45) min after 9 days of exercise, the difference was statistically significant (P
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