Association between NSAIDs and Clostridium difficile-Associated Diarrhea: A Systematic Review and Meta-Analysis

Autor: Nitipong Permpalung, Sikarin Upala, Anawin Sanguankeo, Suthanya Sornprom
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Canadian Journal of Gastroenterology and Hepatology, Vol 2016 (2016)
Druh dokumentu: article
ISSN: 2291-2789
2291-2797
DOI: 10.1155/2016/7431838
Popis: Objective. Clostridium difficile infection is a leading cause of nosocomial diarrhea in developed countries. Studies evaluating the associations of increased risk of community-acquired CDAD and the use of nonsteroidal anti-inflammatory drugs (NSAIDs) have yielded inconclusive results. We conducted a systematic review and meta-analysis to compare the odds of NSAID exposure in patients with CDAD versus patients without CDAD in both community-based and healthcare-associated settings. Methods. Relevant observational studies indexed in PubMed/MEDLINE and EMBASE up to February 2015 were analyzed and data were extracted from nine studies. Of these, eight studies were included in the meta-analysis. Results. A search of the databases resulted in 987 articles. The nine studies from which data were extracted involved over 39,000 subjects. The pooled odds ratio for history of NSAID use in participants with CDAD compared with controls was 1.41 (95% CI 1.06–1.87; p
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