Effect of Vaccination to COVID-19 Disease Progression and Herd Immunity

Autor: Caga-anan Randy L., Raza Michelle N., Labrador Grace Shelda G., Metillo Ephrime B., Castillo Pierre del, Mammeri Youcef
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Computational and Mathematical Biophysics, Vol 9, Iss 1, Pp 262-272 (2021)
Druh dokumentu: article
ISSN: 2544-7297
DOI: 10.1515/cmb-2020-0127
Popis: A mathematical model of COVID-19 with a delay-term for the vaccinated compartment is developed. It has parameters accounting for vaccine-induced immunity delay, vaccine effectiveness, vaccination rate, and vaccine-induced immunity duration. The model parameters before vaccination are calibrated with the Philippines’ confirmed cases. Simulations show that vaccination has a significant effect in reducing future infections, with the vaccination rate being the dominant determining factor of the level of reduction. Moreover, depending on the vaccination rate and the vaccine-induced immunity duration, the system could reach a disease-free state but could not attain herd immunity. Simulations are also done to compare the effects of the various available vaccines. Results show that Pfizer-BioNTech has the most promising effect while Sinovac has the worst result relative to the others.
Databáze: Directory of Open Access Journals