Rare functional variants in the CRP and G6PC genes modify the relationship between obesity and serum C‐reactive protein in white British population

Autor:	Xia Li, Alexander Ploner, Yunzhang Wang, Jonathan K. L. Mak, Yi Lu, Patrik K. E. Magnusson, Juulia Jylhävä, Sara Hägg
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	C‐reactive protein loss‐of‐function variants obesity protein‐altering variants rare genetic variants UK Biobank Genetics QH426-470
Zdroj:	Molecular Genetics & Genomic Medicine, Vol 11, Iss 12, Pp n/a-n/a (2023)
Druh dokumentu:	article
ISSN:	2324-9269
DOI:	10.1002/mgg3.2255
Popis:	Abstract Background C‐reactive protein (CRP) is a sensitive biomarker of inflammation with moderate heritability. The role of rare functional genetic variants in relation to serum CRP is understudied. We aimed to examine gene mutation burden of protein‐altering (PA) and loss‐of‐function (LOF) variants in association with serum CRP, and to further explore the clinical relevance. Methods We included 161,430 unrelated participants of European ancestry from the UK Biobank. Of the rare (minor allele frequency
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/b783b457074d4aa093cac96a0c0f3c33 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.