Reversible cross-linking of gelatin by a disulphide-containing bis-succinimide for tunable degradation and release

Autor: Shengbin He, Jingtong Wang, Zhao Li, Yongqiang Cao, Xueping Ning, Jian Sun, Quanzhi Chen, Min Ling
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Food Chemistry: X, Vol 18, Iss , Pp 100699- (2023)
Druh dokumentu: article
ISSN: 2590-1575
DOI: 10.1016/j.fochx.2023.100699
Popis: Generally, gelatin was irreversibly cross-linked by chemical reagents to improve its water-resistance. However, few chemical reagents meet both the requirements of high cross-inking efficiency and tunable degradation. Here a reversible cross-linker, disulphide-containing bis-succinimide, was synthesized and used to control the cross-linking and degradation of edible gelatin film. Mixture of the gelatin and cross-linker for 120 min generated gelatin films that could preserve their morphology in 37 ℃ warm water for above 40 days. The gelatin film changed its microstructure from net to tightness after the cross-linking, thus facilitating the embedding of the targeted molecule into the gelatin material. The degradation of the cross-linked gelatin film and the release of its inclusion could be controlled by biocompatible glutathione. This work provides a good method for preparing modified gelatin with promising water-resistance, good biocompatibility, and tunable degradation for food/biomedical engineering applications.
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