Lipid‐Based Nanocarriers for The Treatment of Glioblastoma

Autor: Nerea Iturrioz-Rodríguez, Rosalia Bertorelli, Gianni Ciofani
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Advanced NanoBiomed Research, Vol 1, Iss 2, Pp n/a-n/a (2021)
Druh dokumentu: article
ISSN: 2699-9307
20200005
DOI: 10.1002/anbr.202000054
Popis: Glioblastoma multiforme (GBM) is the most common and malignant neoplasia having origin in the brain. The current treatments involve surgery, radiotherapy, and chemotherapy, being complete surgical resection the best option for the patient survival chances. However, in those cases where a complete removal is not possible, radiation and chemotherapy are applied. Herein, the main challenges of chemotherapy, and how they can be overcome with the help of nanomedicine, are approached. Natural pathways to cross the blood–brain barrier (BBB) are detailed, and different in vivo studies where these pathways are mimicked functionalizing the nanomaterial surface are shown. Later, lipid‐based nanocarriers, such as liposomes, solid lipid nanoparticles, and nanostructured lipid carriers, are presented. To finish, recent studies that have used lipid‐based nanosystems carrying not only therapeutic agents, yet also magnetic nanoparticles, are described. Although the advantages of using these types of nanosystems are explained, including their biocompatibility, the possibility of modifying their surface to enhance the cell targeting, and their intrinsic ability of BBB crossing, it is important to mention that research in this field is still at its early stage, and extensive preclinical and clinical investigations are mandatory in the close future.
Databáze: Directory of Open Access Journals
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