Genetically Engineered‐Cell‐Membrane Nanovesicles for Cancer Immunotherapy

Autor: Qinzhen Cheng, Yong Kang, Bin Yao, Jinrui Dong, Yalan Zhu, Yiling He, Xiaoyuan Ji
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Advanced Science, Vol 10, Iss 26, Pp n/a-n/a (2023)
Druh dokumentu: article
ISSN: 2198-3844
35072415
DOI: 10.1002/advs.202302131
Popis: Abstract The advent of immunotherapy has marked a new era in cancer treatment, offering significant clinical benefits. Cell membrane as drug delivery materials has played a crucial role in enhancing cancer therapy because of their inherent biocompatibility and negligible immunogenicity. Different cell membranes are prepared into cell membrane nanovesicles (CMNs), but CMNs have limitations such as inefficient targeting ability, low efficacy, and unpredictable side effects. Genetic engineering has deepened the critical role of CMNs in cancer immunotherapy, enabling genetically engineered‐CMN (GCMN)‐based therapeutics. To date, CMNs that are surface modified by various functional proteins have been developed through genetic engineering. Herein, a brief overview of surface engineering strategies for CMNs and the features of various membrane sources is discussed, followed by a description of GCMN preparation methods. The application of GCMNs in cancer immunotherapy directed at different immune targets is addressed as are the challenges and prospects of GCMNs in clinical translation.
Databáze: Directory of Open Access Journals
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