| Autor: |
Tian-Yan Ding, Yu-Hui Peng, Chao-Qun Hong, Bin-Liang Huang, Can-Tong Liu, Yun Luo, Ling-Yu Chu, Biao Zhang, Xin-Hao Li, Qi-Qi Qu, Yi-Wei Xu, Fang-Cai Wu |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Discover Oncology, Vol 13, Iss 1, Pp 1-14 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2730-6011 |
| DOI: |
10.1007/s12672-022-00591-1 |
| Popis: |
Abstract Background Esophagogastric junction adenocarcinoma (EJA) lacks serum biomarkers to assist in diagnosis and prognosis. Here, we aimed to evaluate the diagnostic and prognostic value of serum insulin-like growth factor binding protein 3 (IGFBP3) in EJA patients. Methods 320 participants were recruited from November 2016 to January 2020, who were randomly divided into a training cohort (112 normal controls and 102 EJA patients including 24 early-stage patients) and a validation cohort (56 normal controls and 50 EJA patients including 12 early-stage patients). We used receiver operating characteristics curve (ROC) to evaluate diagnostic value. The predictive performance of the nomogram was evaluated by the concordance index (C-index). Results Serum IGFBP3 levels were significantly lower in early-stage EJA or EJA patients than those in controls (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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