| Autor: |
Sonal Singh, Helen R. Warren, Timo P. Hiltunen, Caitrin W. McDonough, Nihal El Rouby, Erika Salvi, Zhiying Wang, Tatiana Garofalidou, Frej Fyhrquist, Kimmo K. Kontula, Valeria Glorioso, Roberta Zaninello, Nicola Glorioso, Carl J. Pepine, Patricia B. Munroe, Stephan T. Turner, Arlene B. Chapman, Eric Boerwinkle, Julie A. Johnson, Yan Gong, Rhonda M. Cooper‐DeHoff |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 16 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2047-9980 |
| DOI: |
10.1161/JAHA.119.013115 |
| Popis: |
BackgroundThere exists a wide interindividual variability in blood pressure (BP) response to β1‐blockers. To identify the genetic determinants of this variability, we performed a pharmacogenomic genome‐wide meta‐analysis of genetic variants influencing β1‐blocker BP response.Methods and ResultsGenome‐wide association analysis for systolic BP and diastolic BP response to β1‐blockers from 5 randomized clinical trials consisting of 1254 patients with hypertension of European ancestry were combined in meta‐analysis and single nucleotide polymorphisms (SNPs) with P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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