Hyaluronic acid accelerates bone repair in human dental sockets: a randomized triple-blind clinical trial

Autor: Carlos Eduardo Pinto ALCÂNTARA, Maurício Augusto Aquino CASTRO, Mariana Saturnino de NORONHA, Paulo Antônio MARTINS-JUNIOR, Renato de Melo MENDES, Marcelo Vidigal CALIARI, Ricardo Alves MESQUITA, Anderson José FERREIRA
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Brazilian Oral Research, Vol 32, Iss 0 (2018)
Druh dokumentu: article
ISSN: 1807-3107
DOI: 10.1590/1807-3107bor-2018.vol32.0084
Popis: Abstract This study evaluated the effects of hyaluronic acid (HA) on bone repair of human dental sockets. Thirty-two lower first premolars were extracted from 16 patients (2 per patient) for orthodontic reasons. Following the extractions, one socket was randomly filled with 1% HA gel, while the other was allowed to naturally fill with blood clot. After 30 and 90 days of surgery, patients underwent cone beam computed tomography. Five central orthoradial slices were captured from each socket. The gray intensity was measured in each image and results were reported as mean percentage of bone formation. The buccolingual alveolar ridge width was measured and dimensional changes were compared between the postoperative intervals. The pattern of alveolar trabecular bone was evaluated through the fractal dimension. Treated sockets showed a higher percentage of bone formation and fractal dimension values (58.17% and 1.098, respectively) compared with controls (48.97% and 1.074, respectively) in the 30-day postoperative period (p < 0.05). After 90 days, there was no significant difference between groups. Additionally, no significant difference was found between groups regarding the alveolar dimensions (p > 0.05). Use of 1% HA gel after tooth extraction accelerates bone repair in human dental sockets.
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