| Autor: |
Zhi Chen, Fen Wang, Wen Zhang, Shuangshuang Zhou, Di Wen, Ren Mu |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Ecotoxicology and Environmental Safety, Vol 253, Iss , Pp 114693- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
0147-6513 |
| DOI: |
10.1016/j.ecoenv.2023.114693 |
| Popis: |
Oxidative stress was one of the major causes of heavy metal-induced toxicity in organisms. The polysaccharide from Bletilla striata (Orchidaceae) (BSP) has been recently recognized as a novel player in the management of oxidative stress response in organisms. Here, we took the midgut of adult Drosophila melanogaster (Diptera: Drosophilidae) (D. melanogaster), a functional equivalent to the mammalian intestine and stomach, as a model to evaluate the protective effects of BSP (50 μg/mL) on mercuric chloride-induced gastrointestinal toxicology in insects. As a result, BSP exposure significantly improved the survival rates and climbing ability of adult flies exposed to mercury. Further study demonstrated that BSP significantly alleviated the mercury-induced oxidative injury to midgut epithelium, at least partly, through increasing antioxidant enzyme activity (glutathione-S-transferase and superoxide dismutase), decreasing reactive oxidative species production, inhibiting cell death, restoring intestinal epithelial barrier and regulating intestinal stem cell-mediated tissue regeneration. Additionally, sestrin, an oxidative-stress gene, was required in mediating the protection of BSP against mercury-induced oxidative damage to midgut. This study suggested that BSP has great potential for future application in the treatment and prevention of heavy metal-induced gastrointestinal adversities in mammals. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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